Severe Blunt Muscle Trauma in Rats: Only Marginal Hypoxia in the Injured Area

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Severe Blunt Muscle Trauma in Rats: Only Marginal Hypoxia in the Injured Area

BACKGROUND After severe muscle trauma, hypoxia due to microvascular perfusion failure is generally believed to further increase local injury and to impair healing. However, detailed analysis of hypoxia at the cellular level is missing. Therefore, in the present work, spectroscopic measurements of microvascular blood flow and O2 supply were combined with immunological detection of hypoxic cells ...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0111151